WebFeb 11, 2015 · Cefepime is a parenteral fourth-generation cephalosporin with an extended spectrum of antimicrobial activity that is routinely prescribed for variety of hospital acquired infections. It is considered well tolerated and is associated with few adverse reactions. Cefepime-related neurological toxicity is well described in patients with renal ... WebJun 6, 2024 · We report a case of cefepime neurotoxicity characterised by myoclonic status epilepticus with coma, in a context of acute renal failure and requiring one discontinuous conventional haemodialysis. Cefepime is a fourth-generation broad-spectrum cephalosporin mainly used to treat hospital-acquired Gram-negative infections.
Cefepime plasma concentrations and clinical toxicity: a …
WebOct 10, 2024 · Mean onset of neurotoxicity symptoms was 5 days (SD = 4) after cefepime initiation. Electroencephalogram (EEG) was performed to aid diagnosis in 81% of cases. ... If the pathophysiology of toxicity is truly mediated by the GABA receptor, it is possible that benzodiazepines or phenobarbital would be the best pharmacologic choices . However ... WebNational Center for Biotechnology Information how i met your father date
National Center for Biotechnology Information
WebSep 1, 2024 · The symptoms were seen within four to five days of initiating the treatment and resolved within three days of discontinuation of cefepime. ... This report highlights atypical presentation of cefepime induced toxicity with focal neurological symptoms despite absence of structural abnormalities on MRI of the brain and the possibility of ... WebFeb 10, 2024 · Toxicity. In the event of a suspected overdose, the clinician should discontinue the drug or adjust the dose. Determining if the symptoms result from an actual cefepime overdose or preexisting comorbidities may be difficult. If suspicion is high or symptoms do not subside after dose adjusting or discontinuing, blood and/or cerebral … WebThe primary outcome was the incidence of clinical toxicity among patients receiving cefepime TDM. Toxicity was prospec-tively categorized by organ system. Neurotoxicity potentially related to cefepime was first identified by documentation of consistent neurological symptoms and/or signs according to the high grade urothelial papillary carcinoma