Chloramphenicol is an antibiotic useful for the treatment of a number of bacterial infections. This includes use as an eye ointment to treat conjunctivitis. By mouth or by injection into a vein, it is used to treat meningitis, plague, cholera, and typhoid fever. Its use by mouth or by injection is only recommended when … See more The original indication of chloramphenicol was in the treatment of typhoid, but the presence of multiple drug-resistant Salmonella Typhi has meant it is seldom used for this indication except when the organism is known … See more Chloramphenicol is extremely lipid-soluble; it remains relatively unbound to protein and is a small molecule. It has a large apparent volume of distribution and penetrates … See more Chloramphenicol was first isolated from Streptomyces venezuelae in 1947 and in 1949 a team of scientists at Parke-Davis including See more Although its use in veterinary medicine is highly restricted, chloramphenicol still has some important veterinary uses. It is currently … See more Aplastic anemia The most serious side effect of chloramphenicol treatment is aplastic anaemia. … See more Chloramphenicol is a bacteriostatic agent, inhibiting protein synthesis. It prevents protein chain elongation by inhibiting the peptidyl transferase activity of the bacterial ribosome. It specifically binds to A2451 and A2452 residues in the 23S rRNA of the 50S ribosomal … See more Names Chloramphenicol is available as a generic worldwide under many brandnames and also under various generic names in eastern Europe and Russia, including chlornitromycin, levomycetin, and chloromycetin; the … See more WebWhen used by eye: Chloramphenicol 0.5% eye drops (in max. pack size 10 mL) and 1% eye ointment (in max. pack size 4 g) can be sold to the public for treatment of acute …
Chloramphenicol Drugs BNFC NICE
WebChloramphenicol is a broad spectrum antibiotic that is effective against a variety of susceptible and serious bacterial infections but is not frequently used because of its high risk of bone marrow toxicity. An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. Webchloramphenicol + colchicine contraindicated in pts w/ renal or hepatic impairment; otherwise use alternative or monitor CBC; decr. colchicine dose based on indication during and w/in 14 days of chloramphenicol use as follows: GOUT PROPHYLAXIS: give colchicine 0.3 mg qod-qd; ACUTE GOUT TX: avoid combo if already receiving colchicine … blagrove house swindon
Chloramphenicol - an overview ScienceDirect Topics
WebAug 26, 2024 · Farmakologi chloramphenicol atau kloramfenikol adalah sebagai antibiotik dengan efek bakteriostatik. Chloramphenicol dapat larut dalam lemak, sehingga bisa memasuki membran sel bakteri, kemudian berikatan dengan subunit 50S pada ribosom bakteri. Akibatnya, pembentukan rantai peptida dan sintesis protein bakteri terganggu. … Web1. Noun, singular or mass. Bactrim is most frequently prescribed, while Baytril is sometimes used for adult piggies and chloramphenicol and doxycycline are used on … WebJul 4, 2024 · Chloramphenicol is a medication used in the management and treatment of superficial eye infections such as bacterial conjunctivitis, and otitis externa. It has also been used for the treatment of typhoid and cholera. Chloramphenicol is an antibiotic and is in the class of antimicrobials that inhibits protein synthesis. bl agro oil