Cisplatin-induced apoptosis

Author: ivig

August undefined, 2024

WebOct 15, 2001 · cis-platinum(II) (cis-diammine dichloroplatinum; cisplatin) is a potent antitumor compound that is widely used for the treatment of many malignancies. An important side-effect of cisplatin is nephrotoxicity, which results from injury to renal tubular epithelial cells and can be manifested as either … WebCisplatin-induced nuclear DNA (nDNA) damage in dorsal root ganglion (DRG) neurons has been thoroughly investigated. Cisplatin covalently binds to nuclear DNA (nDNA) inducing DNA damage and apoptosis. Cisplatin-induced DNA damage up-regulates p53 and induces cell cycle changes in DRG neurons.

Current Oncology Free Full-Text Blockade of ALDH in Cisplatin ...

WebApr 11, 2024 · Cisplatin induced DNA damage activates JNK and p73 and promotes their complex formation and leads to apoptosis. Cisplatin induces stabilization of p18 (Hamlet), a protein regulated by p38 MAPK. This enhances the ability of p53 to interact with and activate pro-apoptotic genes, PUMA and NOXA Full size image WebNov 7, 2024 · Cisplatin binds to DNA and induces DNA-damage culminating in mitochondria-mediated apoptosis. Interestingly, mitochondrial DNA is critically affected … cpwd form 26

Neferine mitigates cisplatin-induced acute kidney injury in mice …

WebMechanisms of Cisplatin-Induced Apoptosis and of Cisplatin Sensitivity: Potential of BIN1 to Act as a Potent Predictor of Cisplatin Sensitivity in Gastric Cancer Treatment Cisplatin … WebThe role of intra- and extracellular pH in apoptosis induction was investigated. Activation of caspase-3 and DNA ladder formation were used to monitor the apoptotic response. … WebDec 12, 2024 · Cisplatin is one of the most generally used and highly effective chemotherapy drugs for the treatment of various types of human cancer, such as testicular, ovarian, head and neck, bladder, bone,... distressed baseball clipart black and white

Acute apoptosis by cisplatin requires induction of reactive …

Cisplatin-induced apoptosis

Current Oncology Free Full-Text Blockade of ALDH in Cisplatin ...

WebDec 8, 2024 · We observed that combined treatment with mdivi-1 and cisplatin induced downregulation of c-FLIP expression (Figure 2 C). c-FLIP is a major anti-apoptotic protein and is involved in death receptor-mediated apoptosis and chemotherapeutic drug resistance in cancer cells . To investigate the role of c-FLIP downregulation in combined … WebAim: To investigate the synergetic effect and the mechanism of antitumor action of the antibiotic lidamycin in combination with cisplatin in vitro. Methods: Cytotoxicity of the drugs was measured by clonogenic assay. Chromatin condensation was observed by co-staining with fluorescent dyes, Hoechst 33342 and propidium iodide. Apoptotic sub-G1 was …

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WebThe chemotherapeutic drug cisplatin elicits cytotoxicity causing renal tubular cell death, but its executing mechanisms of action are versatile and elusive. Here, we show that cisplatin induces renal tubular cell apoptosis and ferroptosis by … WebOct 16, 2006 · Cisplatin is a broad-spectrum anticancer drug that is also widely used in experimental studies on DNA damage-induced apoptosis. Induction of apoptosis within 24–48 hr requires cisplatin concentrations that are …

WebJul 1, 1999 · Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer … WebCisplatin (cis-diamminedichloroplatinum (II), DDP) is an antineoplastic agent widely used in the treatment of solid tumors because of its extensive cytotoxic activity. However, the main limiting side effect of DDP use is nephrotoxicity, a rapid deterioration in kidney function due to toxic chemicals. Several studies have shown that epigenetic processes are involved in …

WebThis study investigated non-targeted metabolomic analysis on ABs and medium from apoptotic HK-2 cells induced with cisplatin or exposure to UV light. ... We did not mean that these differences will result in differences in the extension of apoptosis induced by ABs because we knew from our previous work published in Biochimica et Biophysica … WebOct 5, 2014 · Cisplatin-Induced Cell Apoptosis Apoptosis is a controlled type of cell death which is energy-dependent leading to cell shrinkage, chromatin condensation, …

WebMoreover, DSF sensitized ovarian cancer cells to cisplatin treatment and enhanced cisplatin-induced apoptosis, both in SDC and MDC. In the present studies, we have used a quantitative method to determine synergism or antagonism of DSF in chemotherapy drug treatment. Three pairs of two-drug combinations and a three-drug combination were …

WebMay 16, 2024 · Apoptosis level was detected by caspase 3/7 activity and DNA fragmentation. Results: The increased LC3-II accumulation, p62 clearance, the number of LC3-positive puncta, and ALs in cisplatin-treated cells suggested that cisplatin indeed induces autophagy. distressed black and copper coffee tableWebJul 1, 1999 · Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer cell lines We have assessed in detail the effect of cisplatin-activated programmed cell death in the cisplatin-sensitive human ovarian cancer cell line A2780 and two drug-resistant … cpwd form 8WebNov 3, 2024 · Apoptosis is known as one of the major mechanisms of cisplatin-induced cell death in renal tubular which had been further confirmed in some studies [ 5, 6 ]. Some research data have also demonstrated that autophagy induction is an immediate response of renal tubular epithelial cell exposure to cisplatin [ 7, 8 ]. distressed bib overalls