WebMar 23, 2024 · For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10-20% of all cancer patients. Although nephrotoxicity associated with platinum-based agents is well recognized, treatment of cisplatin-induced acute kidney injury is mainly su … WebMay 22, 2024 · Bismuth Porphyrin Antagonizes Cisplatin-Induced Nephrotoxicity via Unexpected Metallothionein-Independent Mechanisms Bismuth Porphyrin Antagonizes Cisplatin-Induced Nephrotoxicity via Unexpected Metallothionein-Independent Mechanisms iScience. 2024 May 22;23 (5):101054. doi: 10.1016/j.isci.2024.101054. …
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WebThe manufacturer recommends that an alerting mechanism be instituted to verify any order for cisplatin >100 mg/m. 2. per course every 3-4 weeks. ... induced diuresis to effectively decrease cisplatin-induced nephrotoxicity. 7. Refer to protocol by which patient is being treated. Numerous hydration regimens exist. WebSep 1, 2024 · The mechanism of cisplatin-induced nephrotoxicity (CIN) has long been investigated in order to develop preventive/therapeutic drugs. Ferroptosis is a newly … things to do in trenton georgia
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WebCis-dichlorodiammine platinum (II), or cisplatin, is currently among the most widely used agents in the chemotherapy of cancer. The chief limit to its greater efficacy is its … WebOct 5, 2014 · The disproportionate accumulation of cisplatin in kidney tissue contributes to cisplatin-induced nephrotoxicity (Arany and Safirstein, 2003). Biosynthesis of amino acid lysine and methionine yields a quaternary ammonium compound called Carnitine, which is required for the transport of fatty acids from the cytosol into the mitochondria during ... WebThe proteinuria associated with cisplatin nephrotoxicity is attributed to a tubular defect. 32 Hemolytic uremic syndrome has also been described, especially when cisplatin is combined with bleomycin. 33 Sequential … things to do in toyota city japan