Cisplatin transporter

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August undefined, 2024

WebCisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, ... membrane-bound mechanosensitive sodium … WebDec 14, 2024 · Cisplatin (CDDP) is a chemotherapy drug commonly used in systemic treatment of germ cell tumors, including cancers of the ovaries, testes, and solid tumors of the head and neck 1.

Role of membrane transportors in cisplatin induced …

WebMar 9, 2024 · SLC11A2, also known as DMT1 (divalent metal transporter 1), is a metal transporter that has been shown to control the pool of cytoplasmic iron 32, therefore affecting the drug activation step... WebFeb 10, 2024 · Cisplatin is a chemotherapeutic drug widely used to treat various types of cancers, including testicular, ovarian, bladder, head and neck, lung, and cervical cancers. However, patients treated with cisplatin frequently suffer from nausea, vomiting, fatigue, serious kidney problems, tinnitus and hearing loss. how to spell team

Cisplatin in cancer therapy: molecular mechanisms of action

WebAug 1, 2016 · Cisplatin Pazopanib Renal transporters OCT-2 Drug-drug interaction 1. Introduction Angiogenesis inhibitors represent a promising approach in the treatment of … WebOct 5, 2014 · The uptake of cisplatin is mediated by the copper transporter Ctr1 in yeast and mammals (Ishida, Lee et al., 2002). It has been further confirmed in human cells that cisplatin triggers rapid degradation of the copper membrane transporter CTR1, with diminished influx of cisplatin, resulting in resistance to the drug ( Lin, Okuda et al., 2002 ... WebSep 18, 2024 · NCBI Bookshelf how to spell teamers in spanish

EGCG Enhances Cisplatin Sensitivity by Regulating Expression of

IJMS Free Full-Text Multifaceted Mechanisms of Cisplatin …

WebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in … WebDiscussion. In a previous study, we showed that DM was the high-risk factor for cisplatin-induced AKI. 5 However, no attempt was made to identify the mechanism for the development of AKI in patients with DM. MATE1/SLC47A1, an organic cation transporter in proximal tubular epithelial cells, mediates the tubular secretion of cationic drugs or … rdve subholding s.aWebApr 14, 2024 · Flavonoids are enriched in various vegetables, fruits, and herbal products, and some were reported to produce transporter-mediated DDIs. This study aimed to screen potential inhibitors of OCT2 from 96 flavonoids, assess the nephroprotective effects on cisplatin-induced kidney injury, and clarify the structure-activity relationships of ... rdvgynecofeminae gmail.com

"Web(mate1) mediate cellular transport of cisplatin. Transporter mediated uptake has been shown to be an important process mediating cellular accumulation of cisplatin. Cisplatin is one of the most widely utilized antitumor drugs in the world [6]. Cisplatin was the first platinum-based drug that revolutionized the treatment of neoplastic diseases. " - Cisplatin transporter

Cisplatin transporter

Cisplatin in cancer therapy: molecular mechanisms of action

WebSep 6, 2012 · Cisplatin is a potent cytostatic drug, whose use is limited by its severe acute and chronic nephro-, oto-, and peripheral neurotoxicity. For this reason, other platinum derivatives, such as carboplatin and oxaliplatin, with less toxicity but still with antitumoral action have been developed. WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 …

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WebFeb 23, 2007 · Ctr1, the major copper influx transporter, has been convincingly demonstrated to transport cisplatin and its analogues, carboplatin, and oxaliplatin. Evidence also suggests that the two copper efflux transporters ATP7A and … Webwww.ncbi.nlm.nih.gov

WebHydroxytyrosol protects against cisplatin-induced nephrotoxicity via attenuating CKLF1 mediated inflammation, and inhibiting oxidative stress and apoptosis. ... of cisplatin in suppression of hepatocellular carcinoma via inhibiting CKLF1 mediated NF-κ B pathway and regulating transporter mediated drug efflux. Journal of Ethnopharmacology, 2024 ... WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different …

WebFeb 23, 2007 · Ctr1, the major copper influx transporter, has been convincingly demonstrated to transport cisplatin and its analogues, carboplatin, and oxaliplatin. … WebApr 30, 2015 · Cisplatin is one of the first-line platinum-based chemotherapeutic agents for treatment of many types of cancer, including ovary cancer. CTR1 (copper transporter 1), a transmembrane solute carrier transporter, has previously been shown to increase the cellular uptake and sensitivity of cisplatin. It is hypothesized that increased CTR1 …

WebJul 1, 2024 · The remaining cisplatin can transport to tumor cells by passive diffusion through plasma membrane [31], [44], [47]. Modern studies reveal that copper transporter protein CTR1 is also responsible for cisplatin uptake [48]. Cisplatin causes degradation of concentration of CRT1, resulting in lower cisplatin accumulation by the cancer cells.

WebApr 5, 2024 · Cisplatin is a platinum containing drug first approved as an antineoplastic agent in 1978. It remains an important and effective therapy in many forms of cancer today. Cisplatin mediates its tumorcidal effects via a number of different cytotoxic mechanisms. Although it is best known for DNA damage, cisplatin also causes cytoplasmic organelle … how to spell tear as in ripWebCisplatin, or cis-diamminedichloridoplatinum(II) cis-[PtCl 2 (NH 3) 2], is a platinum-based anticancer drug largely used for the treatment of various types of cancers, including … rdvi fact sheetWebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … how to spell teammateWebJan 17, 2024 · System x c − is one among many amino acid transporters expressed in the plasma membrane of mammalian cells 1.This transporter is composed of xCT (SLC7A11), which is the substrate-specific ... how to spell tearingWebSep 15, 2024 · DESCRIPTION. Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 mL … rdvmonanesthesiste.frWebThe direction of MATE1 transport is defined by the proton concentration gradient: when assayed in vitro at pH 7.4 or higher, MATE1 behaves as an uptake transporter, whereas … rdvemg hopital-foch.comWebFeb 28, 2024 · However, the principal mechanisms by which 13 and, above all, 18 overcome cisplatin resistance rely on three different possible mechanisms: the inhibition of endogenous P-gp expression, a transporter that enables the active efflux of the drug from the cancer cells; the generation of ROS inside the cells that can reduce GSH levels, a … rdviewer.com