Diabetogenic action
WebApr 30, 2024 · Observational studies and meta-analyses of randomized clinical trials data have revealed a 10–12% increased risk of new-onset diabetes (NOD) associated … WebMar 4, 2024 · The underlying diabetogenic action of statins likely results from a complex interplay between pancreatic and extrapancreatic effects. Nevertheless, cardiovascular protection by statin treatment outweighs the risks associated with development of new-onset diabetes or modest deterioration of glucose control in individuals with diabetes [ 3 ].
Diabetogenic action
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WebThe diabetogenic component (here called adipokinetic .AK) would play its role in: (1) liberating fatty acids from adipose tissue, thus shifting cellular metabolism to the … WebThe diabetogenic component (here called adipokinetic .AK) would play its role in: (1) liberating fatty acids from adipose tissue, thus shifting cellular metabolism to the utilization of fat, whenever there develops a relative scarcity of carbohydrate. This shift would inhibit glucose use and lead to insulin resistance, ketone production, etc.
WebMay 8, 2024 · Direct Metabolic Functions: GH is anabolic. It stimulates the growth of almost all tissues of the body that are capable of growing (increase in the number of cells). GH also increases the rate of protein synthesis in most cells of the body and decreases the rate of glucose utilization throughout the body (diabetogenic action). WebThe diabetogenic action of STZ in laboratory animals was discovered during early testing of this natural product for anticancer activity (Rakieten et al. 1963). It …
WebThe diabetogenic action of statins - mechanisms and clinical implications Treatment with statins has transformed primary and secondary prevention of cardiovascular disease (CVD), including thrombotic stroke. WebDec 15, 2015 · Figure 2: Potential sites of action of statins on β-cell function identified from in vitro studies. ( 1) Statins reduce mRNA and protein expression of GLUT2, limiting glucose uptake. ( 2) Statins...
WebJan 1, 1997 · Abstract. Streptozotocin, which induces diabetes mellitus in experimental animals, has been reported to be taken up by β-cells by means of the glucose transporter 2 (GLUT2) and then reduce the cellular level of NAD +, leading to necrosis of the β-cells.We investigated the effect of insulin pretreatment on the diabetogenic action of …
WebMay 15, 2001 · Streptozotocin (STZ), an analogue of GlcNAc, inhibits purified rat spleen O -GlcNAc-selective N -acetyl-β- d -glucosaminidase (O-GlcNAcase), the enzyme that … inateck configuration sheetWebTHE diabetogenic effect of both crude anterior pituitary extract and purified growth hormone in the dog and cat is now well established. Originally demonstrated with crude anterior pituitary extract, (Johns et. al, 1927, Evans, ... in addisonWebCotes and coworkers described the diabetogenic action of pure anterior pituitary growth hormone in cats.In intact adult dogs and cats the repeated administration of growth hormone induces an intensively diabetic condition with all symptoms of diabetes including severe ketonuria and ketonemia. inateck copyWebDiabetes is a chronic metabolic disorder that adversely affects the body's ability to manufacture and use insulin, a hormone necessary for the conversion of food into energy. The disease greatly increases the risk of … inateck code barreWebMay 8, 2024 · Mechanism of action: similar to oxytocin, it acts on its target cells via a G-protein coupled receptor, which activates phospholipase C that in turn stimulates phosphoinositide turnover and causes an increase in … inateck capture card softwareWebdiabetogenic: ( dī'ă-bet'ō-jen'ik, -bē-tō-jen'ik ), Causing diabetes. inateck customer supportWebJan 19, 2012 · Alloxan, a well- known diabetogenic agent is widely used to induce type 2 diabetes in animals [ 22 ]. The drug and its reduction product dialuric acid establish a redox cycle with the formation of superoxide radicals. These radicals undergo dismutation to hydrogen peroxide. in addition adverbial synonym