WebAug 11, 2024 · EIF4A3, a member of the DEAD-box protein family, is a nuclear matrix protein and a core component of the exon junction complex (EJC). Under physiological conditions, EIF4A3 participates in post-transcriptional gene regulation by promoting EJC control of precursor mRNA splicing, thus influencing nonsense-mediated mRNA decay. WebDec 3, 2024 · EIF4A3 is a core component of the exon junction complex (EJC), playing significant roles in mRNA splicing, location, transport, translation, and degradation. 30, 31, 32 As a RBP, EIF4A3 has been reportedly implicated in interacting with RNAs and is considered as a diagnostic marker or therapeutic target for several cancers.

EIF4A3 eukaryotic translation initiation factor 4A3 [ (human)]

WebMar 31, 2016 · View Full Report Card. Fawn Creek Township is located in Kansas with a population of 1,618. Fawn Creek Township is in Montgomery County. Living in Fawn … WebIn vitro EIF4A3-silencing (or pharmacological inhibition) resulted in reduced aggressiveness, and hindered xenograft-tumours growth in vivo, whereas EIF4A3 overexpression increased tumour aggressiveness. EIF4A3-silencing altered the expression and splicing of key HCC-related genes, specially FGFR4. farm stuff near me

Frontiers Eukaryotic Initiation Factor 4A-3: A Review of Its ...

WebAug 4, 2024 · Eukaryotic initiation factor 4A-III (eIF4A3), a core helicase component of the exon junction complex, is essential for splicing, mRNA trafficking, and nonsense … WebABSTRACT. EIF4A3 (eukaryotic translation initiation factor 4A3) is an RNA helicase and core component of the exon junction complex. While this RNA-binding protein (RBP) is well-characterized for its crucial roles in splicing, RNA trafficking and nonsense-mediated decay, its role in the regulation of metabolic signaling pathways remains elusive. farms tunbridge wells