Ephrin-a2
WebNov 11, 2010 · Ephrin-A2 can be released from the plasma membrane after cleavage by ADAM10/Kuzbanian (Fig. 1E; Hattori et al. 2000). A cleavage-resistant version of ephrin-A2 strongly delays the repulsion of Eph receptor-presenting axon growth cones, which indicates that proteolytic processing helps to terminate Eph/ephrin-mediated cell interactions. WebEphrin-A2 expression was correlated with Ki-67 expression in PCa patients, both at the gene scale and protein level. Our data indicate that Ephrin-A2 is a potential diagnostic and prognostic biomarker and a promising molecular therapeutic target to attenuate prostate cancer progression
Ephrin-a2
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WebMouse Ephrin-A2 Antibody Summary Species Reactivity Mouse Specificity Detects mouse Ephrin-A2 in direct ELISAs and Western blots. In direct ELISAs, less than 1% cross‑reactivity with recombinant mouse (rm) Ephrin-A1, rmEphrin-A4, and rmEphrin-A5 is observed. Source Polyclonal Goat IgG Purification Antigen Affinity-purified Immunogen WebThe mRNA expression of Ephrin A2 in normal tissue compared to renal cell carcinoma samples. The EphA2 mRNA expression in normal kidney tissue versus papillary RCC patient sample using Jones Dataset of ONCOMINE (ONCOMINE is a Cancer Microarray Database and Integrated Data-Mining Platform) database. The EphA2 mRNA expression …
WebPurpose/Background: Ephrin A2 (EphA2), a receptor tyrosine kinase, is frequently over expressed in colorectal cancer (CRC). EphA2 high CRCs are associated with increased rates of metastases, poorer survival and higher levels of resistance to chemotherapy. The normal function of EphA2 is to facilitate tissue patterning and direct tissue growth ... WebMethods: Ephrin A2 expression was determined by Western analysis of total protein isolated from acoustic ganglia in normal animals. Protein localization was characterized by fluorescence immunohistochemisty in sections of acoustic ganglia of normal and gentamicin treated animals. Patterns of ephrin A2 expression in acoustic ganglia were ...
WebSep 18, 2024 · Ephrin-A2 reverse signaling regulates neocortical progenitor proliferation We further investigated the relationship between ephrin-A2 and cell cycle and whether this effect was mediated through...
WebEphrin receptors (Ephs) are receptor tyrosine kinases (RTKs) implicated in tissue development and homeostasis, and they are aberrantly expressed in tumors. Here, immunohistochemical Eph type-A and -B expression in thymic epithelial tumors (TETs) was assessed and correlated with clinicopathological parameters. Tissue microarrays from 98 …
WebMar 21, 2024 · EFNA2 (Ephrin A2) is a Protein Coding gene. Diseases associated with EFNA2 include Craniofrontonasal Syndrome and Craniosynostosis . Among its related pathways are Nervous system development and EPH-Ephrin signaling . Gene Ontology (GO) annotations related to this gene include ephrin receptor binding . An important … dr puskar infectious disease melbourneWebProtein target information for Ephrin type-A receptor 2 (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments. dr puskas orthopedicWebEphrin-A2 and -A3 are negative regulators of the proliferative and neurogenic potentials of Müller cells. Manipulating ephrin-A signaling may thus represent a novel strategy for stimulating neuroregeneration from endogenous progenitors to participate in retinal repair in case of disease or damage. dr putchaWebEphrin‑A2, also known as ELF‑1, HEK7‑L, LERK‑6, and EPLG6, is an approximately 20 kDa member of the GPI‑linked Ephrin‑A family of proteins that bind and induce the tyrosine autophosphorylation of Eph receptors. college of policing app mappaWebApr 9, 2024 · The presence of normal visual acuity (~0.5 cycles per degree) in ephrin-KO mice is surprising because there is evidence that at least some of the abnormal and ectopic connections in the visual system of ephrin-A2 −/− and ephrin-A2/A5 −/− mice are functional and would therefore be expected to disrupt the continuity and/or coherence of ... college of policing app log inWebFeb 9, 2024 · Within the developing avian limb bud, ephrin-A2, localized predominantly to the proximal-intermediate regions, regulates the “position-specific” affinity of limb mesenchymal cells, while also contributing to cartilage patterning within the limb ( … college of policing app footballWebSmall molecules are one of the two main approaches for targeted cancer therapy. 14 The main targets for small molecules are kinases, especially tyrosine kinase. 15 Erythropoietin-producing hepatocellular A2 belongs to the Eph subfamily, which is the largest RTK family. 16 EphA2 is highly expressed in multiple cancers, including lung cancer ... drpu software adon