WebFeb 17, 2024 · Children and Adolescents weighing ≥40 kg: Note: Doses should be based on lean body weight for patients within a normal weight range for their height (optimal … WebJan 14, 2010 · This study is designed to measure drug concentrations in the blood of healthy volunteers administered a single dose of ethambutol. Our hypothesis is that volunteers …
Ethambutol-induced optical neuropathy: Risk of overdosing in obese ...
WebIn obese patients, weight-based dosing is likely best based on measurements of ideal (versus total) body weight. ** Maximum dose regardless of weight. ¶¶ For patients with creatinine clearance <30 mL/min (by Cockroft-Gault equation) or for patients receiving intermittent hemodialysis, ethambutol dosing consists of 20 to 25 mg/kg (ideal body ... WebFor obese patients dosage requirement may best be estimated using an adjusted body weight (ABW) of: IBW + 0.4 (TBW - IBW).1 ... ethambutol, rifamycin and possibly an aminoglycoside. The decision to add an aminoglycoside depends on multiple factors including the extensiveness of disease, drug-refractory/resistant profile, and drug … ice \\u0026 slice swadlincote
Influence of Morbid Obesity on the Clinical Pharmacokinetics
WebSep 1, 2010 · We are concerned about the proposed ethambutol dosing algorithm for obese patients using ideal body weight. Although their study demonstrated ethambutol … WebCurrent dosage recommendations are based on total body weight (TBW); drug toxicity might result in obese patients receiving TBW doses. Peak and trough serum levels were … WebBackground: Ethambutol (EMB) is one of the first-line drugs in the treatment against tuberculosis (TB). Side-effects are infrequent, but its main adverse effect, optical neuropathy, has long been recognised. ... 0.8% were EMB-related. We present the six cases; four were clearly overdosed, but in two obese patients dosage was correctly ... moneypenny mentoring