Golph3 autophagy

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August undefined, 2024

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WebMay 1, 2024 · Golgi phosphoprotein 3 ( GOLPH3 ), a cytosolic phosphoprotein, was identified as the first oncoprotein of the Golgi apparatus through combining to phosphatidylinositol 4-phosphate (PI4P). WebFeb 21, 2024 · In this study, we aimed to investigate whether and how Golgi phosphoprotein 3 (GOLPH3) facilitates colon cancer metastasis via the regulation of … download indian movie badrinath ki dulhania

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WebApr 1, 2024 · Significance This study unveiled a new selective autophagy of the Golgi apparatus (Golgiphagy). In addition, GOLPH3 might act as a novel cargo receptor to regulate Golgiphagy. Maintaining... WebDec 28, 2024 · Modification of Golgi morphology, GM130 decrease and autophagy by ICH; Reverse effects and neuroprotective effects by overexpression of GM130 (Deng et al., 2024) HIF-1α/HO-1 pathway: Regulation of oxidative stress: ALI: Increase of GM130, MAN2A1, Golgin 97 and decrease of GOLPH3 by activation of HIF-1α/HO-1 pathway; Reverse … Web开馆时间：周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆 download indian instrumental music

The Golgi as an Assembly Line to the Autophagosome

WebJul 15, 2024 · This study unveiled a new selective autophagy of the Golgi apparatus (Golgiphagy). In addition, GOLPH3 might act as a novel cargo receptor to regulate … WebMar 29, 2024 · We aimed to examine whether golgi protein GOLPH3 could affect the secretion of glioma cell-derived exosomes. The exosomes were extracted by ultra-centrifugation from the supernatant of U251 and U87 cell cultures and identified by transmission electron microscopy (TEM), Malvern analyzer, and western blot. The … class 7 all books pdf nctbWebAutophagy: Recycles damaged cell parts into fully functioning cell parts. Gets rid of nonfunctional cell parts that take up space and slow performance. Destroys pathogens in a cell that can damage it, like viruses and bacteria. Autophagy plays an important role when it comes to aging and longevity, too. download indian memes

"WebJul 11, 2024 · The primary antibodies were used at the following dilutions: STK25 (1:1000, Cat #25821–1-AP, Proteintech), GOLPH3 (1:1000, Cat #19112–1-AP, Proteintech), PDHK1 (1:1000, Cat #3820, Cell Signaling Technology), HK2 (1:1000, Cat #2867, Cell Signaling Technology), LDHA (1:1000, Cat #2012, Cell Signaling Technology), AKT (1:1000, Cat … " - Golph3 autophagy

Golph3 autophagy

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WebJan 31, 2024 · Golgi phosphoprotein 3 (GOLPH3), a Phosphatidylinositol 4-Phosphate [PI(4)P] effector at the Golgi, is required for Golgi ribbon structure maintenance, vesicle trafficking and Golgi glycosylation. GOLPH3 has been validated as an oncoprotein through combining integrative genomics with clinopathological and functional analyses. It is … WebMay 15, 2024 · In this study, we demonstrated that Golgi phosphorylation protein 3 (GOLPH3), a highly conserved protein basically concentrates in the trans-Golgi network, promoted glioma autophagy. Inhibiting autophagy by using chloroquine suppressed the stimulating effect of GOLPH3 on glioma malignant development both in vitro and in vivo.

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WebResults. We screened 344 DE circRNAs in unstable plaques, consisting of 342 upregulated and 2 downregulated circRNAs. GO analysis showed that the host genes of the upregulated circRNAs were related to ER to Golgi transport vesicle membrane, endocytic vesicle membrane, and Ran GTPase binding. WebRegulation of the Golgi apparatus via GOLPH3-mediated new selective autophagy Author: Li-qun Lu, Ming-zhu Tang, Zhi-hao Qi, Shi-fang Huang, Yong-qi He, Dian-ke Li, Lan-fang …

WebMay 15, 2024 · In this study, we demonstrated that Golgi phosphorylation protein 3 (GOLPH3), a highly conserved protein basically concentrates in the trans-Golgi network, … WebNov 13, 2024 · GOLPH3 is stimulated by oxidative stress and is involved in signal transduction , while GOLPH3 silencing contributed towards alleviating GA stress …

WebGOLPH3L is a GOLPH3 paralog that acts as a dominant negative inhibitor of the GOLPH3 pathway due to its ability to bind to PtdIns (4)P, while being unable to bind to MYO18A (Ng et al., 2013).... WebTKI can trigger EGFR translocation, in the autophagy compartment , in mitochondria or in nucleuses . Dysregulation of EGFR trafficking plays an essential role in cancer progression and response to anti-EGFR therapies. ... GOLPH3 has been reported to enhance the anti-tumoral activity of gefitinib in GBM cell lines , suggesting that Rab5 ...

WebSep 3, 2024 · Previous studies on the peripheral Golgi membrane protein GOLPH3 and its paralogue GOLPH3L (herein I will refer to both proteins as GOLPH3) indicated it can bind to certain Golgi enzymes and to the COPI coat, thereby acting as an adaptor to mediate sorting of these enzymes into COPI vesicles (4, 5).This was first shown for the yeast orthologue …

WebJan 7, 2014 · GOLPH3 is a PI4P-binding protein that depends on PI4P for its Golgi localization [ 20 ]. The GOLPH3-interacting protein MYO18A localizes to the cell cortex in addition to the Golgi. Tan et al. raised the possibility that GOLPH3 and MYO18A have additional roles outside of the Golgi [ 91 ]. class 7 assignment 18 weak answerWebMay 31, 2024 · Rahman et al. create Atg8a-LDS (LIR motif docking site) mutants in Drosophila. They show that Atg8a-LDS mutants accumulate autophagy substrates and have reduced lifespan. Using quantitative proteomics, they identify Golgi protein GMAP as a LIR motif-containing protein that interacts with Atg8a. They show that GMAP LIR mutants … download indian mp3WebDec 20, 2014 · This study aims to investigate the effect of Golgi Protein 73 (GP73) on autophagy in human hepatoma line cells HepG2. We investigated the functional effects of GP73 on autophagy in hepatoma … class 7 all ncert books