Web14 dec. 2024 · Extensive studies of 3-HYDROXY-3-METHYLGLUTARYL (HMG)-COA REDUCTASE DEGRADATION (Hrd1) and DEGRADATION OF ALPHA2 (Doa10) … Web4 aug. 2014 · We were the first to demonstrate SEL1L as an indispensable component of HRD1 ERAD complex in mammals in vivo (PNAS 2014), discover novel links between SEL1L-HRD1 ERAD and a number of disease-associated proteins and pathways including IRE1a, prohormones and lipoprotein lipase (Nat Cell Biol 2015; Mol Biol Cell 2016; J Clin …
Hrd1 forms the retrotranslocation pore regulated by auto …
WebQuality control of endoplasmic reticulum proteins involves the identification and engagement of misfolded proteins, dislocation of the misfolded protein across the endoplasmic reticulum (ER) membrane, and ubiquitin-mediated targeting to the proteasome for degradation. Ancient ubiquitous protein 1 (AUP1) physically associates with the mammalian HRD1 … Web30 sep. 2015 · Instead, gp78 appears to act downstream of Hrd1 to promote ERAD via cooperation with the BAG6 chaperone complex. We conclude that the Hrd1 complex forms an essential retrotranslocation module that is evolutionarily conserved, but the mammalian ERAD system uses additional ubiquitin ligases to assist Hrd1 during retrotranslocation. hearty kale soup
Natalie Steffen - Director, Global Engagement Lead Omnichannel ...
WebThese results lead to a model in which the Hrd1 channel is regulated by cycles of autoubiquitination and deubiquitination, reactions that are modulated by the other components of the Hrd1 complex ... Web3 jan. 2012 · Recently, HRD3A and HRD1 were reported to be ERAD components in plants that were responsible for the degradation of bri1-9 and bri1-5 ( Liu et al., 2011; Su et al., 2011 ), but no ubiquitin conjugating enzyme in the ERAD pathway has been reported in … Web18 jan. 2024 · Cryo-EM structure of Hrd1/Hrd3 monomer PDB DOI: 10.2210/pdb6VJY/pdb EM Map EMD-21220: EMDB EMDataResource Classification: PROTEIN TRANSPORT Organism (s): Saccharomyces cerevisiae Expression System: Saccharomyces cerevisiae Mutation (s): No Membrane Protein: Yes OPM PDBTM MemProtMD mpstruc Deposited: … hearty k bop