WebNational Center for Biotechnology Information WebKLF2 is a member of the Krüppel-like transcription factor family of proteins containing highly conserved DNA-binding zinc finger domains. KLF2 participates in the differentiation and regulation of the functional activity of monocytes, T lymphocytes, adipocytes, and vascular endothelial cells.
KLF2 - an overview ScienceDirect Topics
WebMay 19, 2024 · Exposure to chronic infection or malignant tumors triggers the differentiation of functionally impaired, so-called exhausted T cells. In this issue of Immunity, Beltra et al. reveal a multi-step developmental process that defines how T cells transition from proliferating progenitors into terminally differentiated exhausted T cells. Webexhausted T (Tex) cells.12-15 TCF-1-centered anscrtr iptional network plays an important role in CD8 + T cells and provides many key targets for immunotherapy. Therefore, in … alina colceru
Early precursor T cells establish and propagate T cell exhaustion …
WebNov 25, 2010 · KLF2 (lung Krüppel-like factor) is expressed in lung, endothelial cells, and lymphocytes. 19–24 KLF2 deficiency is embryonic lethal because of severe hemorrhage resulting from defects in blood vessel integrity. 19 In T-cell biology, KLF2 has been demonstrated to regulate T-cell properties of quiescence, survival, activation, and … WebMar 1, 2024 · KLF2, a member of the Kruppel-like factor family, has diverse roles in the immune system, and in particular plays a critical role in controlling migration of T (and … WebApr 14, 2024 · T cell exhaustion is an alternative differentiation path of T cells, sometimes described as a dysfunction. During the last decade, insights of T cell exhaustion acting as … alina cohrs