Mitoferrin regulation

Author: psbm

August undefined, 2024

Web22 sep. 2009 · Mitoferrin-1 (Mfrn1; Slc25a37), a member of the solute carrier family localized in the mitochondrial inner membrane, functions as an essential iron importer for … Web12 aug. 2015 · Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2. Paradkar PN, Zumbrennen KB, Paw BH, Ward DM, …

Mitochondrion-mediated iron accumulation promotes …

Web20 mei 2008 · Mitoferrin-1. Gene. SLC25A37. Status. UniProtKB reviewed (Swiss-Prot) Organism. Homo sapiens (Human) Amino acids. 338. Protein existence. Evidence at … if two lines meet at a right angle they\\u0027re

Mitoferrin, Cellular and Mitochondrial Iron Homeostasis

WebBackground/aim: GDF15, hepcidin and mitoferrin-1 (mfrn-1) are proteins involved in systemic iron regulation. There are no studies in the literature demonstrating the serum … WebIron Regulatory Protein 1 / metabolism* Liver Neoplasms* / genetics Phosphopyruvate Hydratase / genetics RNA, Messenger / genetics Tumor Suppressor Proteins / metabolism Biomarkers, Tumor DNA-Binding Proteins RNA, Messenger Tumor Suppressor Proteins Iron ENO1 protein, human Phosphopyruvate Hydratase ACO1 protein, human Iron … Web3 okt. 2016 · Total body and mitochondrial iron levels were significantly reduced by green tea supplementation in w 1118 and mitoferrin mutants but not transferrin mutant flies. Our results demonstrate that green tea may act to increase the lifespan of Drosophila in part by the regulation of mitoferrin and reduction of mitochondrial iron. is talstar insecticide safe around pets

Regulation of mitochondrial iron import through differential …

Elevating bioavailable iron levels in mitochondria suppresses the ...

WebAbcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Proc. Natl. Acad. Sci. U.S.A. 2009; 106 ... We do not know … WebMitoferrin 1 and mitoferrin 2, two homologues proteins belonging to the mitochondrial solute carrier family, are required for iron delivery into mitochondria. Mitoferrin 1 is … if two loci act independently during meiosis:Web22 aug. 2024 · Cellular iron homeostasis. Cellular iron homeostasis is regulated via iron uptake, trafficking, and export (Fig. 2).These processes are tightly controlled by iron … if two logarithmic fucnctions are multiplied

"Web26 sep. 2014 · Mitoferrin has two isoforms: mitoferrin-1 and mitoferrin-2, which are localized on the inner mitochondrial membrane and function as a requisite importer of iron for mitochondrial heme and iron-sulfur cluster (ISC) in erythroblasts [ 11]. " - Mitoferrin regulation

Mitoferrin regulation

Intron Retention Mechanisms That Regulate SF3B1 and Mitoferrin …

Webimportant for regulating ROS production, which largely facilitates tumor progression and response to therapy. Here, we investigated the role of the mitochondrial iron transporters … Web5 nov. 2024 · For example, mitoferrin (mfrn), a member of the mitochondrial carrier family, is the primary importer transporting iron across the inner mitochondrial membrane. It was …

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WebBecause the bi-functional IRP1 shifts between iron-regulation and metabolism-regulation, this mechanism suggests an interesting link between iron and cellular energy metabolism [95,96,97,98]. IRP1 −/− and IRP2 −/− mice show massive impaired iron homeostasis suggesting that the IRP/IRE system is critical in cellular iron control [ 95 , 98 , 99 ]. Web14 mrt. 2014 · Iron is imported into mitochondria via two transporters: mitoferrin-1 (MFRN1, SLC25A37) and mitoferrin-2 (MFRN2, SLC25A28). ... Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish …

Web2 nov. 2024 · miRNA regulation of mitoferrin-1 has been documented as well. RNA sequencing revealed the downregulation of SLC25A37 mRNA and protein expression, as … Web2 dec. 2016 · In contrast to the dynamic regulation of IR in SF3B1, IR in SLC25A37 (mitoferrin-1) and SLC25A28 (mitoferrin-2) is stably maintained at a high level throughout terminal erythropoiesis. Baseline IR levels for stably retained introns correlate with splice site strength, but are also influenced by deeper intronic elements.

Web2 mrt. 2016 · In this study, we provide evidence, for the first time, that a mitoferrin is regulated by a miRNA. Specifically, we show that miR-8-3p regulates mitoferrin ( bmfrn … Web(2009) Paradkar et al. Molecular and Cellular Biology. Mitoferrin 1 and mitoferrin 2 are homologous members of the mitochondrial solute carrier family. Mitoferrin 1 is required …

Web11 apr. 2024 · Ferroptosis is a mode of cell death regulated by iron-dependent lipid peroxidation. Growing evidence suggests ferroptosis induction as a novel anti-cancer modality that could potentially overcome therapy resistance in cancers. The molecular mechanisms involved in the regulation of ferroptosis are complex and highly dependent …

Web2 mrt. 2006 · Precise regulation of iron transport in mitochondria is essential for haem biosynthesis, haemoglobin production and Fe-S cluster protein assembly during … if two matrices are equal thenWeb1 dec. 2001 · Function. Mitochondrial iron transporter that mediates iron uptake. Probably required for heme synthesis of hemoproteins and Fe-S cluster assembly in non-erythroid … if two mindsWebThese results suggest that mitochondrial iron accumulation is tightly regulated and that controlling mitoferrin levels within the mitochondrial membrane provides a mechanism to regulate mitochondrial iron levels. ACKNOWLEDGMENTS We declare no conflict of interest. if two minors have sex