Phenothiazine toxicity
WebBelow are symptoms of a phenothiazine overdose in different parts of the body. Inability to completely empty the bladder (urinary retention) Rapid, involuntary movements of the face (chewing, blinking, grimaces, and tongue movements) Restlessness linked with repeated foot shuffling, rocking, or pacing (akathisia) WebFeb 22, 2024 · Thorazine belongs to a class of drugs called Antipsychotics, Phenothiazine. It is not known if Thorazine is safe and effective in children younger than 6 month of age. ... Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever and primary central nervous system ...
Phenothiazine toxicity
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WebPhenothiazines also possess peripheral adrenergic receptor blockade and quinidine-like cardiac effects. Phenothiazines may lower the seizure threshold. Clinical signs of toxicity … WebFeb 18, 2013 · Toxicity levels of the compound were determined at the same time. In a separate experiment, the actual bacterial load in various organs was determined in treated and untreated mice. While evaluating the effects of phenothiazines in challenged mice it was noted that Pr was the best drug since it could offer protection at the level of 2–8 µg ...
WebNov 3, 2024 · Toxicokinetics: Rapidly absorbed but in overdose absorption can be slow and erratic. Large volume of distribution and lipid soluble Extensive first pass effect with … WebToxicity of Phenothiazine Compounds. Pediatrics (1959) 23 (5): 1015–1016. I have been very interested in the recent exchange of letters ( Pediatrics, 22: 1201, 1958) regarding the toxicity of the phenothiazine compounds. I have witnessed many cases of typical toxicity to phenothiazine drugs and have made several observations which I would ...
WebPromethazine – Promethazine is the phenothiazine most commonly used in children because it is effective and has a low … Motion sickness …administering amphetamine, but not pseudoephedrine, with promethazine appeared to prevent the sleepiness and impairment of psychomotor performance seen with promethazine alone . WebOf 48 cases of phenothiazine poisoning that were analyzed, 34 were attributed to suicide attempts, nine to accidental ingestion, and five to drug reactions. As outpatient treatment …
WebReproductive toxicity Specific target organ toxicity - single exposure No data available(Phenothiazine) Specific target organ toxicity - repeated exposure Oral - May cause damage to organs through prolonged or repeated exposure.
WebPhenothiazine was formerly used as an insecticide and as a drug to treat infections with parasitic worms (anthelminthic) in livestock and people, but its use for those purposes … the groundwater cycleWebThus, dopaminergic toxicity of rotenone and MPP (+)in vivo can be forestalled by nanomolar concentrations of certain chain-breaking antioxidants irrespective of dopamine receptor modulation or mitochondrial targeting. (c) 2010 Elsevier Inc. All rights reserved. Publication types Research Support, Non-U.S. Gov't MeSH terms Animals the bank hawickthe groundwaterWebNational Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHENOTHIAZINE-air. 10H time-weighted average 5 mg/m 3 (Sk) NIOSH* DHHS … the groundwater instituteWebPhenothiazines, butyrophenones, and other related drugs are used widely to treat psychosis and agitated depression. In addition, some of these drugs (eg, prochlorperazine, promethazine, trimethobenzamide, and droperidol) are used as antiemetic agents. the groundwater approachWeb12.1 Toxicity Toxicity to fish static test LC50 - Oncorhynchus mykiss (rainbow trout) - 0.597 mg/l - 96 h (OECD Test Guideline 203) Remarks: (in analogy to similar products) The value is given in analogy to the following substances: phenothiazine Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - 11.92 mg/l - 48 h the groundwater groupWebOct 25, 2010 · Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. The product contains following substances which are hazardous for the environment. Component Freshwater Algae Freshwater Fish Microtox Water Flea Phenothiazine Not listed LC50: = 1.1 mg/L, 48h (Oryzias latipes) LC50: = 0.579 mg/L, 96h … the groundwater directive