2024 Phf8 cancer

Phf8 cancer

Author: fhna

August undefined, 2024

WebMar 21, 2024 · PHF8 (PHD Finger Protein 8) is a Protein Coding gene. Diseases associated with PHF8 include Intellectual Developmental Disorder, X-Linked, Syndromic, Siderius … WebPHF8 expression is elevated in HER2+ breast cancers and is upregulated by HER2. Prompted by our previous findings of higher expression of PHF8 in HER2+ breast cancer cells and its functional requirement in the anchorage-independent growth of these cells (Shao et al, 2024), we first evaluated . PHF8

PHF8 gene: MedlinePlus Genetics

WebPHF8 HER2 IL-6 Breast cancer Drug resistance 1. Introduction Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer death of American women. Thus, approximately 268,600 new cases of breast cancer will be diagnosed, and approximately 41,760 women will die from breast cancer in 2024 in the United States [1]. WebPHF8-knockout cells showed a marked increase in sensitivity to HU or CPT . Also, PHF8-knockout cells were more vulnerable in the presence of cisplatin , a well-known … flights fll to hav

Histone H3K4Me3 (1-21) (human, mouse, rat, porcine, bovine ...

WebTrimethylation of histone H3 at lysine 4 is found in euchromatic promoter regions and is associated with active transcription. It inhibits several H3K9 methyltransferases and has differential effects on the activities of the KDM7 demethylases PHF8 and KDM7A, activating and inhibiting H3K9Me3 demethylation, respectively. WebApr 4, 2024 · We are currently investigating MAPK-dependent mechanisms controlling PHF8 stability, and testing novel PHF8 inhibitors for their ability to bypass or overcome … WebAug 15, 2014 · Here in this study, we report PHF8 as an oncogenic protein in human non-small cell lung cancer (NSCLC). PHF8 overexpresses in human NSCLC tissues and predicts poor survival. We demonstrate that PHF8 regulates lung cancer cell proliferation and cellular transformation, and PHF8 knockdown induces DNA damage and apoptosis in lung cancer … chengdu food capital

The HIF&PHF8&AR axis promotes prostate cancer …

Phf8 cancer

Chemical Inhibitors Targeting the Histone Lysine Demethylase …

WebNov 28, 2011 · PHF8 mediates cancer cell migration and invasion As modulation of the actin cytoskeleton and integrin signaling are linked to cellular movement ( Guo and Giancotti, 2004 ), we hypothesized that... WebThis April, NYU Langone Health’s Perlmutter Cancer Center researchers and physicians join colleagues from around the world at the American Association for Cancer Research annual meeting in Orlando, Florida. ... 396 / 22 – Role of PHF8 in resistance to melanoma targeted therapies Senior Author: Eva Hernando-Monge, PhD Time: 1:30–5 pm ...

Did you know?

WebUp-regulation of H19 in bladder cancer tissues is correlated with clinical stage or metastasis of cancer. By cell transfection to suppress H19 expression in bladder cancer cells, E-cadherin expression is up-regulated, thus weakening metastatic potency of cancer cells. ... (HCC). PHF8 might be a promising target for prevention, treatment and ...

WebMar 1, 2024 · Serving as a transcription coactivator, PHF8 were shown to be involved in human cancer progression and metastasis. In breast cancer, ubiquitin-specific protease 7 (USP7)-mediated stabilization of PHF8 regulated cyclin A2 expression to promote carcinogenesis [ 14 ]; PHF8 upregulated SNAI1 and ZEB1 to induce an EMT-like process … WebFeb 12, 2024 · The histone demethylase PHF8 regulates TGFβ signaling and promotes melanoma metastasis 2024, Science Advances Targeting the methyltransferase SETD8 impairs tumor cell survival and overcomes drug resistance independently of p53 status in multiple myeloma 2024, Clinical Epigenetics

WebJul 1, 2015 · The histone demethylase PHF8 is an oncogenic protein in human non-small cell lung cancer Biochem. Biophys. Res. Commun. (2014) M.F. Arteaga et al. The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia Cancer Cell (2013) D. Kleine-Kohlbrecher et al. Webstudy reported that PHF8 promotes prostate cancer cell growth by activating miR-125b. 26 However, the underlying mechanism for enhanced PHF8 expression in prostate cancer is …

WebThe histone demethylase PHF8 promotes prostate cancer cell growth by activating the oncomiR miR-125b Qiang Ma,* Zhuo Chen,* Guojin Jia, Xueqiang Lu, Xuefeng Xie, Wei Jin Department of Urology, Jinshan Hospital, Fudan University, Shanghai, People’s Republic of China *These authors contributed equally to this workAims: Prostate cancer (PCa) is the …

WebAug 15, 2014 · PHF8 is a JmjC domain-containing protein and erases repressive histone marks including H4K20me1 and H3K9me1/2. It binds to H3K4me3, an active histone mark usually located at transcription start sites (TSSs), through its plant homeo-domain, and is thus recruited and enriched in gene promoters. PHF8 is involved in the development of … chengdu fish recipeWebWe found that PHF8 plays a minimum role in initiation and progression of adenocarcinoma. However, PHF8 is essential for NEPC because not only is PHF8 highly expressed in NEPC but also animals without Phf8 failed to develop NEPC. Mechanistically, PHF8 … flights fll to florence italyWebSep 21, 2024 · Interestingly, PHF8 is often overexpressed in several malignancies, including prostate cancer , esophagus cancer , lung cancer , laryngeal and hypopharyngeal … flights fll to hsvWebThe histone demethylase PHF8 promotes prostate cancer cell growth by activating the oncomiR miR-125b Qiang Ma,* Zhuo Chen,* Guojin Jia, Xueqiang Lu, Xuefeng Xie, Wei Jin … chengdu fly digital technology co ltdWebApr 1, 2024 · We have reported that histone demethylase PHF8 demethylates TOPBP1 K118 mono-methylation (K118me1) to drive the activation of ATR kinase, one of the master … flights fll to havanaWebDec 6, 2024 · PHF8 PHD finger protein 8 [ (human)] The histone demethylase PHF8 regulates TGFbeta signaling and promotes melanoma metastasis. Histone demethylase … chengdu future cityWebSep 4, 2024 · PHF8 might be a promising target for prevention, treatment and prognostic prediction of HCC. Background Hepatocellular carcinoma (HCC), accounting for 90% of all … chengdu gastone technology