Tmeff2蛋白
WebMar 4, 2024 · Background Transmembrane protein with EGF-like and two follistatin-like domains 2 (TMEFF2) is a transmembrane protein in the tomoregulin family. Little research has been performed to determine whether TMEFF2 methylation is a prognostic marker in adult diffuse gliomas. Methods In this study, we investigated TMEFF2 expression in … Web我们发现作为跨膜蛋白的tmeff2抑制细胞增殖和促进细胞凋亡的作用依赖于其与蛋白酪氨酸磷酸酶shp-1的相互结合。 我们转染TMEFF2 胞内区缺失的质粒后,TMEFF2 与SHP-1 相 …
Tmeff2蛋白
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WebAug 1, 2024 · The extracellular part of TMEFF2 (TMEFF2-ECD) is cleaved by ADAM17 and the membrane-retained fragment is further processed by the gamma-secretase complex. TMEFF2 shedding is increased with cell crowding, a condition associated with the tumour microenvironment, which was mediated by oxidative stress signalling, requiring jun-kinase … WebSep 29, 2024 · tmeff2作为具有表皮生长因子egf样和fs样结构域蛋白,胞外区fs样功能域,可与转化生长因子-β家族(tgf-β超家族)、血管内皮生长因子(vegf)以及血小板衍生生长 …
WebJul 9, 2002 · Ectopic expression of TMEFF2 in DU145 and PC3 cells resulted in their prominent inhibition of growth. Taken together, the results demonstrate that TMEFF2 is a androgen-regulated gene, which can ... Web实验结果表明,OntoProtein作为基因本体嵌入的蛋白质预训练语言模型超越了最优的模型,并在蛋白质-蛋白质相互作用和蛋白质功能预测方面比基线模型产生了更好的性能。
Web我们发现作为跨膜蛋白的tmeff2抑制细胞增殖和促进细胞凋亡的作用依赖于其与蛋白酪氨酸磷酸酶shp-1的相互结合。 我们转染TMEFF2 胞内区缺失的质粒后,TMEFF2 与SHP-1 相互结合的作用减弱,TMEFF2 抑制细胞增殖的能力也明显减弱,提示TMEFF2 可能通过其胞内区 … Web抑制dna损伤修复的几种atri (共济失调毛细血管扩张症和rad3相关蛋白抑制剂)目前处于临床开发中。 至今这些无一获得批准。 在导致本发明的研究工作过程中,发明人惊讶地发现荷有倍癌霉素的ADC与ATR抑制剂的组合不仅显示了组合功效,而且还显示了高度协同效应。
WebTMEFF2(transmembrane protein with EGF-like and two follistatin-like domains 2), a gene encoding a plasma membrane protein with two follistatin-like domains and one epidermal …
WebTMEFF1 and TMEFF2, also known as tomoregulins-1 and -2, are type I transmembrane glycoproteins that contain two extracellular follistatin modules, an extracellular EGF-like … lcbo alexandria hoursWebJNJ-902 is a bispecific antibody that engages TMEFF2–expressing tumor cells and CD3 on T cells. TMEFF2 is a unique prostate cancer lineage antigen with expression independent of androgen receptor signaling and retained throughout disease progression. In preclinical studies, JNJ-902 showed exposure-dependent pro-inflammatory responses, potent ... lcbo allocated offerWebFeb 15, 2024 · TMEFF2 expression predicts poor prognosis in endometrial carcinoma. The 75 cases of endometrial cancer patients were followed until January 30, 2024. The … lcbo amherstview hoursWebMar 4, 2024 · TMEFF2 promoter methylation levels were increased in glioblastoma cells compared with SVG p12 cells (P < 0.001). Inhibition of methylation reduced TMEFF2 methylation and increased its expression in LN229 and T98G cells (P < 0.05). Knockdown of TMEFF2 expression significantly promoted the proliferation of U87MG cells and primary … lcbo agency storeslcbo angry orchardWebtmeff2在多种生理和病理过程中发挥重要作用,包括胚胎发育、神经发育、神经保护和肿瘤发生等。 研究表明,TMEFF2在多种癌症中具有不同的作用。 例如,在乳腺癌、前列腺癌和肺癌等多种肿瘤中,TMEFF2的表达水平明显降低,与肿瘤发生和进展密切相关。 lcbo and rapid testsWeb钠氯离子转运蛋白抗体相关产品人血管紧张素Ⅱ(ANG-Ⅱ) Human Tomoregulin-1(TMEFF1)马还原酶... 欢迎来到 环保在线 请登录 免费注册 产品展厅 收藏该商铺 lcbo annual report 2022